Partial molecular volumes of cholesterol and phosphatidylcholine in mixed bilayers
نویسندگان
چکیده
منابع مشابه
Partial molecular volumes of lipids and cholesterol.
Volumetric measurements are reported for fully hydrated lipid/cholesterol bilayer mixtures using the neutral flotation method. Apparent specific volume data were obtained with the lipids DOPC, POPC and DMPC at T=30 degrees Celsius, DPPC at 50 degrees Celsius, and brain sphingomyelin (BSM) at 45 and 24 degrees Celsius for mole fractions of cholesterol x from 0 to 0.5. Unlike previous cholesterol...
متن کاملMaximum solubility of cholesterol in phosphatidylcholine and phosphatidylethanolamine bilayers.
In any lipid bilayer membrane, there is an upper limit on the cholesterol concentration that can be accommodated within the bilayer structure; excess cholesterol will precipitate as crystals of pure cholesterol monohydrate. This cholesterol solubility limit is a well-defined quantity. It is a first-order phase boundary in the phospholipid/cholesterol phase diagram. There are many different solu...
متن کاملEgg-sphingomyelin and cholesterol form a stoichiometric molecular complex in bilayers of egg-phosphatidylcholine.
Sphingomyelin and cholesterol are membrane lipids that interact to form liquid-ordered phase believed to act as a platform for the organization of signaling proteins. We report analyses of synchrotron X-ray powder diffraction patterns recorded from aqueous dispersions of ternary mixtures of sphingomyelin and phosphatidylcholine from egg yolk and cholesterol to investigate how cholesterol distri...
متن کاملAssess the nature of cholesterol-lipid interactions through the chemical potential of cholesterol in phosphatidylcholine bilayers.
Cholesterol plays a vital role in determining the physiochemical properties of cell membranes. However, the detailed nature of cholesterol-lipid interactions is a subject of ongoing debate. Existing conceptual models, including the Condensed Complex Model, the Superlattice Model, and the Umbrella Model, identify different molecular mechanisms as the key to cholesterol-lipid interactions. In thi...
متن کاملYolk Phosphatidylcholine Bilayers
The activity of (Ca -Mg )ATPase reconstituted into egg yolk phos phatidylcholine liposomes is reduced when the lipid has been oxidized before the reconstitution procedure. It is suggested that the reversible decrease in activity is caused by a decrease of the lipid bilayer thickness due to the shortening of lipid acyl chains during autoperoxidation; the irreversible decrease in the activity is...
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ژورنال
عنوان ژورنال: European Pharmaceutical Journal
سال: 2017
ISSN: 2453-6725
DOI: 10.1515/afpuc-2017-0012